abstract：:The human dentition is a complex adaptive system that is influenced by genetic, epigenetic, and environmental factors. Within this system, is sexual dimorphism related to the growth promotion of the Y chromosome, or to hormonal influences, or both? This study is the first to investigate both primary and permanent toot...

journal_title：Journal of dental research

authors： Ribeiro DC,Brook AH,Hughes TE,Sampson WJ,Townsend GC

更新日期：2013-05-01 00:00:00

abstract：:Recent evidence implicates endothelin in nociception, but it is unclear how endothelin activates trigeminal ganglion (TRG) neurons. In the present study, we investigated the expression of the endothelin receptors ETA and ETB and endothelin-induced responses in rat TRG neurons. Double-immunofluorescence studies demonst...

journal_title：Journal of dental research

authors： Yamamoto T,Ono K,Hitomi S,Harano N,Sago T,Yoshida M,Nunomaki M,Shiiba S,Watanabe S,Nakanishi O,Inenaga K

更新日期：2013-04-01 00:00:00

abstract：:Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without com...

journal_title：Journal of dental research

authors： Abtahi J,Agholme F,Sandberg O,Aspenberg P

更新日期：2013-03-01 00:00:00

abstract：:The whisker pad area (WP) is innervated by the second branch of the trigeminal nerve and experiences allodynia and hyperalgesia following transection of the mental nerve (MN; the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain remain unclear. The ionotropic P2X(7) ATP rece...

journal_title：Journal of dental research

authors： Murasaki K,Watanabe M,Takahashi K,Ito G,Suekawa Y,Inubushi T,Hirose N,Uchida T,Tanne K

更新日期：2013-03-01 00:00:00

abstract：:The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory bi...

journal_title：Journal of dental research

authors： Bostanci N,Oztürk VÖ,Emingil G,Belibasakis GN

更新日期：2013-02-01 00:00:00

abstract：UNLABELLED:Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We have recently reported that MS induces predominantly C-C chemokine li...

journal_title：Journal of dental research

authors： Tsutsumi T,Kajiya H,Goto KT,Takahashi Y,Okabe K

更新日期：2013-01-01 00:00:00

abstract：:Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bonding systems, by the slow action of host-derived matrix metalloproteinases (MMPs). This study tested the null hypothesis that there are no differences in the activities of MMP-2 and -9 after treatment with different etc...

journal_title：Journal of dental research

authors： Mazzoni A,Scaffa P,Carrilho M,Tjäderhane L,Di Lenarda R,Polimeni A,Tezvergil-Mutluay A,Tay FR,Pashley DH,Breschi L

更新日期：2013-01-01 00:00:00

abstract：UNLABELLED:Dental caries affects most adults worldwide; however, the risk factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces. Instead, the actions of some risk factors may be limited to a subset of teeth/surfaces. Therefore, we used hierarchical clustering on tooth surf...

journal_title：Journal of dental research

authors： Shaffer JR,Feingold E,Wang X,Weeks DE,Weyant RJ,Crout R,McNeil DW,Marazita ML

更新日期：2013-01-01 00:00:00

abstract：:Sense of coherence (SOC) has been related to oral health behaviors and oral-health-related quality of life (OHRQoL) in observational studies. This cluster-randomized trial aimed to test the effect of an intervention to enhance SOC on OHRQoL in children. Twelve primary schools were randomly allocated to intervention an...

journal_title：Journal of dental research

authors： Nammontri O,Robinson PG,Baker SR

更新日期：2013-01-01 00:00:00

abstract：:With clinical oral examinations not always possible in health surveys, researchers may instead be invited to add questions to a wider health survey. In such situations, an item is needed which adequately represents both clinical and self-reported oral health. This study investigated the clinical validity of Locker's g...

journal_title：Journal of dental research

authors： Thomson WM,Mejia GC,Broadbent JM,Poulton R

更新日期：2012-11-01 00:00:00

abstract：:The pellicle serves as a multifunctional protective layer, providing, e.g., lubrication and remineralization and also acting as a diffusion barrier. In addition, since the formation of the pellicle precedes the adhesion of micro-organisms, it is also important as a conditioning film. We present a novel approach to stu...

journal_title：Journal of dental research

authors： Sotres J,Pettersson T,Lindh L,Arnebrant T

更新日期：2012-10-01 00:00:00

abstract：:We previously demonstrated that an anti-caries DNA vaccine intranasally administered with recombinant flagellin protein as a mucosal adjuvant enhanced salivary IgA response and conferred better protection against caries. However, the relatively weak immunogenicity of DNA vaccines and the necessity for a large quantity...

journal_title：Journal of dental research

authors： Sun Y,Shi W,Yang JY,Zhou DH,Chen YQ,Zhang Y,Yang Y,He BX,Zhong MH,Li YM,Cao Y,Xiao Y,Li W,Yu J,Li YH,Fan MW,Yan HM

更新日期：2012-10-01 00:00:00

abstract：:We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventiona...

journal_title：Journal of dental research

authors： Liu G,Saxena D,Chen Z,Norman RG,Phelan JA,Laverty M,Fisch GS,Corby PM,Abrams W,Malamud D,Li Y

更新日期：2012-09-01 00:00:00

abstract：:Potentially significant associations between periodontal disease and chronic kidney disease (CKD) have been reported in recent studies. The aim of this cross-sectional study was to investigate the association between serum antibody to the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) and CKD in 215 Jap...

journal_title：Journal of dental research

authors： Iwasaki M,Taylor GW,Manz MC,Kaneko N,Imai S,Yoshihara A,Miyazaki H

更新日期：2012-09-01 00:00:00

abstract：:Focusing public insurance programs on interceptive orthodontics (IO) may increase access for low-income children. This report presents outcomes from a randomized clinical trial (RCT) comparing IO with comprehensive orthodontics (CO) in Medicaid patients. One hundred seventy pre-adolescents with Medicaid-eligible maloc...

journal_title：Journal of dental research

authors： King GJ,Spiekerman CF,Greenlee GM,Huang GJ

更新日期：2012-07-01 00:00:00

abstract：:Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when applied as a pre-conditioner, adding to clinical steps in the placement of adhesives, but their incorporation within dental adhesives has not been fully explored. This study examined the effect of including 2 MMP inhibito...

journal_title：Journal of dental research

authors： Almahdy A,Koller G,Sauro S,Bartsch JW,Sherriff M,Watson TF,Banerjee A

更新日期：2012-06-01 00:00:00

abstract：:The tongue exerts crucial functions in our daily life. However, we know very little about the regulatory mechanisms of mammalian tongue development. In this review, we summarize recent findings of the molecular and cellular mechanisms that control tissue-tissue interactions during tongue morphogenesis. Specifically, c...

journal_title：Journal of dental research

authors： Parada C,Han D,Chai Y

更新日期：2012-06-01 00:00:00

abstract：:The temporomandibular joint (TMJ) undergoes degenerative changes among patients who suffer from arthritis, and yet the pathogenesis of TMJ osteoarthritis and rheumatoid arthritis is poorly understood. We hypothesized that sustained inflammation in the TMJ induces structural abnormalities, and accordingly characterized...

journal_title：Journal of dental research

authors： Wang XD,Kou XX,Mao JJ,Gan YH,Zhou YH

更新日期：2012-05-01 00:00:00

abstract：:The aim of this study was to assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and a low concentration of fluoride (F) on the hardness of enamel subsurface lesions, utilizing a double-blind, randomized, and controlled in situ model. Fifteen individuals wore removable lingual a...

journal_title：Journal of dental research

authors： Kitasako Y,Sadr A,Hamba H,Ikeda M,Tagami J

更新日期：2012-04-01 00:00:00

abstract：:The aim of this study was to compare the effectiveness of dexamethasone administration following arthrocentesis of the temporomandibular joint (TMJ) with a placebo (saline). Twenty-eight participants with TMJ arthralgia were randomly assigned to two groups of a parallel double-blind RCT. In both groups, an arthrocente...

journal_title：Journal of dental research

authors： Huddleston Slater JJ,Vos LM,Stroy LP,Stegenga B

更新日期：2012-02-01 00:00:00

abstract：:Current challenges in adhesive dentistry include over-hydrophilic bonding formulations, which facilitate water percolation through the hybrid layer and result in unreliable bonded interfaces. This study introduces nanogel-modified adhesives as a way to control the material's hydrophobic character without changing the ...

journal_title：Journal of dental research

authors： Morães RR,Garcia JW,Wilson ND,Lewis SH,Barros MD,Yang B,Pfeifer CS,Stansbury JW

更新日期：2012-02-01 00:00:00

abstract：:Branching morphogenesis is essential for the formation of salivary glands, kidneys, lungs, and many other organs during development, but the mechanisms underlying this process are not adequately understood. Microarray and other gene expression methods have been powerful approaches for identifying candidate genes that ...

journal_title：Journal of dental research

authors： Hsu JC,Di Pasquale G,Harunaga JS,Onodera T,Hoffman MP,Chiorini JA,Yamada KM

更新日期：2012-02-01 00:00:00

abstract：:The Tp63 gene encodes for multiple isoforms of the p63 transcription factor, a member of the p53 family of proteins. Much like its more famous sibling, the biological role of p63 is quite complex, with wide-ranging effects on development, differentiation, and cellular lineage choices. The crucial function of p63 is ep...

journal_title：Journal of dental research

authors： Romano RA,Solomon LW,Sinha S

更新日期：2012-02-01 00:00:00

abstract：:Amelogenin gene organization varies from 6 exons (1,2,3,5,6,7) in amphibians and sauropsids to 10 in rodents. The additional exons are exons 4, 8, 9, and "4b", the latter being as yet unidentified in AMELX transcripts. To learn more about the evolutionary origin of these exons, we used an in silico approach to find th...

journal_title：Journal of dental research

authors： Sire JY,Huang Y,Li W,Delgado S,Goldberg M,Denbesten PK

更新日期：2012-01-01 00:00:00

abstract：:Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis usin...

journal_title：Journal of dental research

authors： Ioannidou E,Swede H,Dongari-Bagtzoglou A

更新日期：2011-12-01 00:00:00

abstract：:Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or impl...

journal_title：Journal of dental research

authors： Larjava H,Koivisto L,Häkkinen L,Heino J

更新日期：2011-12-01 00:00:00

abstract：:Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction. Conversely, targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic de...

journal_title：Journal of dental research

authors： Han XL,Liu M,Voisey A,Ren YS,Kurimoto P,Gao T,Tefera L,Dechow P,Ke HZ,Feng JQ

更新日期：2011-11-01 00:00:00

abstract：:We conducted a school-based parallel cluster randomized controlled trial with 36-month follow-up of children aged 7 to 8 years. Primary schools were randomly assigned to 2 groups: 3 applications of fluoride varnish (22,600 ppm) each year or no intervention. The primary outcome was DFS increment in the first permanent ...

journal_title：Journal of dental research

authors： Milsom KM,Blinkhorn AS,Walsh T,Worthington HV,Kearney-Mitchell P,Whitehead H,Tickle M

更新日期：2011-11-01 00:00:00

abstract：UNLABELLED:The aim of this observational study was to investigate the features of the chewing activity and the variability of the human chewing pace, as assessed in the natural environment. It was hypothesized that the chewing pace is relatively constant within individuals across different days but is variable across i...

journal_title：Journal of dental research

authors： Po JM,Kieser JA,Gallo LM,Tésenyi AJ,Herbison P,Farella M

更新日期：2011-10-01 00:00:00

abstract：:The aim of this meta-analysis was to examine the clinical effectiveness of miniscrew implants (MI) used for anchorage reinforcement compared with that of conventional orthodontic means, as well as to assess the success rates of MIs and the possible risk factors affecting their clinical effectiveness. Literature search...

journal_title：Journal of dental research

authors： Papadopoulos MA,Papageorgiou SN,Zogakis IP

更新日期：2011-08-01 00:00:00

abstract：:The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized hydrophilic resin components and degradation of water-rich, resin-sparse collagen matrices by matrix metalloproteinases (MMPs) and cysteine ca...

journal_title：Journal of dental research

authors： Liu Y,Tjäderhane L,Breschi L,Mazzoni A,Li N,Mao J,Pashley DH,Tay FR

更新日期：2011-08-01 00:00:00

abstract：:The fatigue crack growth resistance of dentin was characterized as a function of depth from the dentino-enamel junction. Compact tension (CT) specimens were prepared from the crowns of third molars in the deep, middle, and peripheral dentin. The microstructure was quantified in terms of the average tubule dimensions a...

journal_title：Journal of dental research

authors： Ivancik J,Neerchal NK,Romberg E,Arola D

更新日期：2011-08-01 00:00:00

abstract：:Gingival overgrowth tissues have thickened connective tissue stroma, sometimes accompanied by the increased presence of collagen fibers, thickened epithelia, and elongated rete pegs. We have previously shown that expression of CCN2, also known as connective tissue growth factor (CTGF), correlates positively with the d...

journal_title：Journal of dental research

authors： Kantarci A,Nseir Z,Kim YS,Sume SS,Trackman PC

更新日期：2011-07-01 00:00:00

abstract：:The purpose of this study was to determine the role of saliva-derived biomarkers and periodontal pathogens during periodontal disease progression (PDP). One hundred human participants were recruited into a 12-month investigation. They were seen bi-monthly for saliva and clinical measures and bi-annually for subtractio...

journal_title：Journal of dental research

authors： Kinney JS,Morelli T,Braun T,Ramseier CA,Herr AE,Sugai JV,Shelburne CE,Rayburn LA,Singh AK,Giannobile WV

更新日期：2011-06-01 00:00:00

abstract：:Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We hypothesized that MS induces expression of osteoclastogenesis-associated chemok...

journal_title：Journal of dental research

authors： Goto KT,Kajiya H,Nemoto T,Tsutsumi T,Tsuzuki T,Sato H,Okabe K

更新日期：2011-06-01 00:00:00

abstract：:Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, ...

journal_title：Journal of dental research

authors： Werneck RI,Lázaro FP,Cobat A,Grant AV,Xavier MB,Abel L,Alcaïs A,Trevilatto PC,Mira MT

更新日期：2011-06-01 00:00:00

abstract：:Symphyseal secondary cartilage is important for mandibular development, but the molecular mechanisms underlying its formation remain largely unknown. Here we asked whether Indian hedgehog (Ihh) regulates symphyseal cartilage development and growth. By embryonic days 16.5 to 18.5, Sox9-expressing chondrocytes formed wi...

journal_title：Journal of dental research

authors： Sugito H,Shibukawa Y,Kinumatsu T,Yasuda T,Nagayama M,Yamada S,Minugh-Purvis N,Pacifici M,Koyama E

更新日期：2011-05-01 00:00:00

abstract：:Previous research, in which the bonding effectiveness of the 3 self-etch monomers HAEPA, EAEPA, and MAEPA was determined, showed that MAEPA was most effective. In this study, the molecular interactions of these monomers with hydroxyapatite and dentin were investigated by combining x-ray diffraction, infrared spectrosc...

journal_title：Journal of dental research

authors： Yoshihara K,Yoshida Y,Hayakawa S,Nagaoka N,Torii Y,Osaka A,Suzuki K,Minagi S,Van Meerbeek B,Van Landuyt KL

更新日期：2011-05-01 00:00:00

abstract：UNLABELLED:The aim of this cross-over, randomized, single-blinded trial was to examine whether intra-esophageal acidification induces sleep bruxism (SB). Polysomnography with electromyogram (EMG) of masseter muscle, audio-video recording, and esophageal pH monitoring were performed in a sleep laboratory. Twelve healthy...

journal_title：Journal of dental research

authors： Ohmure H,Oikawa K,Kanematsu K,Saito Y,Yamamoto T,Nagahama H,Tsubouchi H,Miyawaki S

更新日期：2011-05-01 00:00:00

abstract：:Fluorides are present in the environment. Excessive systemic exposure to fluorides can lead to disturbances of bone homeostasis (skeletal fluorosis) and enamel development (dental/enamel fluorosis). The severity of dental fluorosis is also dependent upon fluoride dose and the timing and duration of fluoride exposure. ...

journal_title：Journal of dental research

authors： Everett ET

更新日期：2011-05-01 00:00:00